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All life on Earth is related

November 1, 2018

Today we will take a deep dive into evolutionary history to talk about the origins of life on Earth.  Drawing from David Quammen’s new book, The Tangled Tree, we will tell you about “a radical new history of life,” as promised by the subtitle of his book. (1)

Categorizing Nature

Throughout written history, humans have demonstrated a compelling need to name and categorize everything in our world, including nature.  Naming and categorizing passes for understanding and enables us to talk about issues using commonly understood definitions.

Linnaean taxonomy was one of the first and most influential attempts to classify the natural world into three kingdoms:  plants, animals, and minerals.  Since Systema naturae was published by Carl Linnaeus in the 18th century, many other classification systems have been proposed by subsequent generations of scientists.

The conventional wisdom about classifying nature changed radically after the discovery of the molecular structure of DNA in the 1950s and the molecular analysis that it enabled in the 1960s.  Genetic analysis revealed the evolutionary relationships between organisms, enabling the development of phylogenetic “trees” depicting those relationships.

Haeckel’s Tree of Life, 1879

The revolutionary work of Charles Darwin was instrumental in initiating such speculation about evolutionary history.  Such theories about the history of life on Earth were often depicted as “trees of life,” showing the progression of evolution.  One of the earliest of such “trees” was published in the 1870s, shortly after the publication of Darwin’s Origin of Species in 1859.

In 1977, using molecular analysis, Carl Woese published his hypothesis of a new kingdom of life, Archaea.  He proposed a new categorization of all life on Earth, which he called domains:  Bacteria, Archaea, Eucarya.  Bacteria and Archaea are one-celled organisms without a nucleus.  Eucarya are every other living organism, including plants, animals, and fungi. Kingdoms of life were relegated to the second level of taxonomy (the classification of organisms).

The hypothesis of Woese was challenged, often contentiously, for decades, but is now conventional wisdom among scientists of phylogenetics, as the genetics of evolution is called.  However, as tidy as these new categories might appear, they aren’t.  As human intellectual constructs often are, many species of life defy neat categorization.  Around the edges of every domain there are many species of life that don’t entirely fit the criteria.  Likewise, around the edges of every genus and species, there are many gray areas.  Just as the distinction between “native” and “non-native” is often ambiguous, so is the categorization of many organisms.  This is a reminder that we must use such definitions with humility, always being prepared to consider a new hypothesis that improves our understanding.

Domains of life

Revising the mechanisms of evolution

Molecular analysis has also radically altered our understanding of how evolution proceeds.  Charles Darwin’s hypothesis about evolution was that change in organisms occurs through genetic variation from one generation to the next.  Occasional genetic mutations from one generation to the next was later added to what is called “vertical evolution.”  Each subsequent generation of a species is tested by the environment and that test is called natural selection.  The individual member of a species that is best adapted to the environment survives to reproduce, while less well-adapted individuals do not survive to reproduce.

In addition to discovering a new domain of life, Carl Woese also discovered that species in one domain of life also exchange genetic material with another domain of life, as well as exchanges between different species within domains.  This is called “horizontal gene transfer.”  The discovery of horizontal gene transfer (HGT) has revolutionized how we think about evolution.  Natural selection remains as the mechanism that confers success or failure on such changes in genes from one generation to another.

Significance of horizontal gene transfer

Horizontal gene transfers occurred in deep time, but are known to be a significant issue at the present time.  Horizontal gene transfer is the primary mechanism for the spread of antibiotic resistance in bacteria and plays an important role in the evolution of bacteria that can degrade synthetic compounds such as pesticides. Antibiotic resistance in one species of bacteria can be transferred to another species of bacteria, multiplying the incidence of antibiotic resistance. (2)

The introduction of chloroplasts into plant cells roughly 3.5 billion years ago was one of the most significant events in the evolution of life on Earth.  The introduction of chloroplasts into plant cells was an example of a horizontal gene transfer from a bacteria cell into eucarya cells.  Chloroplasts are the organelles (specialized structures inside eucarya cells that perform specific functions) that perform photosynthesis in plant cells.  Photosynthesis enables plants to convert the energy of the sun into carbohydrates that feed the plant and emit oxygen as its waste product.  Photosynthesis converts carbon dioxide into oxygen.  This neat trick of photosynthesis radically altered the atmosphere by reducing carbon dioxide and increasing oxygen.  Just as increased carbon dioxide in the atmosphere is now increasing temperatures on Earth, lower carbon dioxide levels in the atmosphere reduced temperatures.  This so-called “Great Oxidization Event” was the probable cause of one of the five great extinctions hundreds of millions of years ago. (3)

The horizontal gene transfer of mitochondria from bacteria cells to eucarya cells was equally significant to the evolution of life on Earth.  Mitochondria are organelles in eucarya cells that perform respiration and energy production functions in most eucarya species of both plants and animals. (2)

The list of such horizontal gene transfers is long.  Here are some examples to help you understand that HGT is an extremely important evolutionary mechanism, perhaps even more important than vertical evolution (2):

• From bacteria to fungi
• From bacteria to plants
• From organelle to organelle
• From plant to plant
• Fungi to insects
• From bacteria to insects
• From viruses to plants
• From bacteria to animals
• From plants to animals
• From plant to fungus

Implications of horizontal gene transfer

Our bodies contain more microbes, such as bacteria, than they do human cells.  Those microbes are interacting with our own cells.  Sometimes the microbes cause problems and sometimes they solve problems.  The microbes in our bodies cannot be called enemies or friends.  Sometimes their interactions with our cells permanently alter our genes and are inherited by our offspring.  Such permanent alterations of our genes are called horizontal gene transfer.  Such interactions between microbes and cells occurs in all life forms, altering plants, animals, etc. 

What are the implications of these interactions?

  • All life forms on Earth are related. No life form on Earth can be considered “alien.”  Every organism on Earth is constantly undergoing change, as it interacts with other organisms.  No “species” is immutable in the long term.
  • Critics of genetic engineering say it is “unnatural” and risky because it introduces genes into organisms in which they did not evolve naturally. But horizontal gene transfer does exactly the same thing and it is a “natural” process.  Genetic engineering is risky, just as HGT is, but it is mimicking a natural process.
  • Many pesticides are known to kill bacteria. Since bacteria are resident in our bodies in huge numbers and are known to sometimes be beneficial, it seems unnecessarily risky to kill them with pesticides.   As with genetic engineering, the risk should be weighed against potential benefits.  Are the risks worth taking?
  • Epidemiological studies report correlation between increased pesticide applications and increased birth defects in humans. Laboratory studies on rats report birth defects in rats exposed to low doses of glyphosate as well as birth defects in subsequent generations of the exposed rats: “A 2018 study of pregnant rats exposed to low doses of glyphosate-based herbicides revealed that the rats had difficulties in getting pregnant and surviving the pregnancy. The second generation offspring suffered from being smaller than normal. They were also afflicted with abnormalities developed before birth. This means the glyphosate-based weed killers inoculate their victims with monstrosities.” (4) These studies suggest that genes may have been altered by pesticide exposure.

 

5 Comments leave one →
  1. Patricia Cotterill permalink
    November 1, 2018 9:20 am

    It is amazing how you guys can take a scientific fact, in this case horizontal gene transfer, and turn it into an anti-pesticide rant! The two are not connected. I haven’t read David Quammen’s book yet, I admit, but I am pretty certain he would not have made that connection. Yes, environmental influences can affect genes negatively, radiation being fingered as the chief culprit, but this is not the same as horizontal gene transfer. Also, I’m wondering if it would give you any comfort to think that all life is related if you were dying of viral or bacterial pneumonia!

    • November 1, 2018 12:38 pm

      Not having read the book or study or whatever an article is based on, never prevents Patty from having an opinion.

      I don’t consider the article an “anti-pesticide rant.” Rather it asks readers to consider risks and weigh them against potential benefits. This is too nuanced for Patty and her friends. For them, everything is good or bad, black or white.

      Patty says, “Yes, environmental influences can affect genes negatively, radiation being fingered as the chief culprit, but this is not the same as horizontal gene transfer.” Nor does the article say that horizontal gene transfer is caused by “environmental influences.” The article is silent on the important question of what causes HGT because there are many causes and each is complex beyond the reach of this article intended for the general public. If Patty wishes to know the causes, she should read the book.

  2. November 1, 2018 12:07 pm

    Good article, thank you.

  3. November 3, 2018 10:15 am

    Sounds like a great book for me to read this winter. Thank you. Since I work growing new species of food plants or those with little modern breeding, I also see the mistakes of my predecessors early on in the breeding process. In general, telling them of their errors in breeding and mentioning the excessive pesticide use to raise food crops makes them very upset. They are very sensitive to critique.To them everything is fine and why change? It is amazing the relationships plants have with all life forms and the connections that are created over time.

    • November 3, 2018 10:36 am

      Thanks, Ken. Yes, it’s amazing how resistant people are to the realities of pesticides, particularly those who use them in their work. That’s true of both agriculture and the “restoration” industry.

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